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PAN4ND
Natural Products
Natural Products
Natural products are chemical substances produced by living organisms (plants,
bacteria, fungi and marine organisms, insects,…). A substance is considered a natural
product even if it can be prepared by total synthesis.
Natural products can either be issued from primary or the secondary metabolism (as
primary metabolites or secondary metabolites).Biodiversity represents the sum of
all living organisms.
NP Databases and useful links
NP Journals
NP Papers of interest (related to Neglected Diseases)
Newman, D. J., G. M. Cragg, et al. (2003). "Natural products as sources of new drugs
over the period 1981-2002." J Nat Prod 66(7): 1022-1037.
Hoet, S., F. Opperdoes, et al. (2004). "Natural products active against African
trypanosomes: a step towards new drugs." Natural Product Reports 21(3): 353-364.
Salem, M. M. and K. A. Werbovetz (2006). "Natural products from plants as drug
candidates and lead compounds against leishmaniasis and trypanosomiasis." Curr Med
Chem 13(21): 2571-98.
Crump, A. (2006). "New medicines from nature's armamentarium." Trends Parasitol 22
(2): 51-4. Epub 2006 Jan 10.
Cos, P., A. J. Vlietinck, et al. (2006). "Anti-infective potential of natural products: How to
develop a stronger in vitro 'proof-of-concept'." Journal Of Ethnopharmacology 106(3):
290-302.
Rocha, L. G., J. R. G. S. Almeida, et al. (2005). "A review of natural products with
antileishmanial activity." Phytomedicine 12(6): 514-535.
Koehn, F. E. and G. T. Carter (2005). The evolving role of natural products in drug
discovery. Nature Reviews Drug Discovery 4(3): 206-220.
Balunas, M. J. and A. D. Kinghorn (2005). Drug discovery from medicinal plants. Life Sci
78(5): 431-41. Epub 2005 Sep 29.
Yamada, Y. (2002). "[Studies on discovery and synthesis of bioactive marine organic
molecules]." Yakugaku Zasshi 122(10): 727-43.
Schwikkard, S. and F. R. v. Heerden (2002). "Antimalarial activity of plant metabolites."
Nat Prod Rep 19(6): 675-692.
Fournet, A. and V. Muñoz (2002). "Natural products as trypanocidal, antileishmanial and
antimalarial drugs." Curr Top Med Chem 2(11): 1215-1237.
Chan-Bacab, M. J. and L. M. Pena-Rodriguez (2001). "Plant natural products with
leishmanicidal activity." Natural Product Reports 18(6): 674-688.
Camacho, M. d. R., J. D. Phillipson, et al. (2004). "In vitro antiprotozoal and cytotoxic
activities of some alkaloids, quinones, flavonoids, and coumarins." Planta Med 70(1): 70-
72.
Kayser, O., A. F. Kiderlen, et al. (2003). "Natural products as antiparasitic drugs."
Parasitol Res 90: S55-S62.
External Links
bacteria, fungi and marine organisms, insects,…). A substance is considered a natural
product even if it can be prepared by total synthesis.
Natural products can either be issued from primary or the secondary metabolism (as
primary metabolites or secondary metabolites).Biodiversity represents the sum of
all living organisms.
NP Databases and useful links
- ChemIDplus
- Webelements
- Dictionary of Natural Product
- NCI database
- FDA website
- Traditional Chinese Medicine Information Database
- Missouri Botanical Garden Databases (Tropicos)
- Royal Botanical Gardens, Kew Data
- The International Plant Names Index
NP Journals
- Phytochemistry
- Journal of Natural Products
- Natural Product Report
- Journal of Ethnopharmacology
- Planta Medica
- Phytochemical Analysis
- Natural Product Update
- Current Organic Chemistry
- Current Medicinal Chemistry
- Drug Discovery Today
NP Papers of interest (related to Neglected Diseases)
Newman, D. J., G. M. Cragg, et al. (2003). "Natural products as sources of new drugs
over the period 1981-2002." J Nat Prod 66(7): 1022-1037.
Hoet, S., F. Opperdoes, et al. (2004). "Natural products active against African
trypanosomes: a step towards new drugs." Natural Product Reports 21(3): 353-364.
Salem, M. M. and K. A. Werbovetz (2006). "Natural products from plants as drug
candidates and lead compounds against leishmaniasis and trypanosomiasis." Curr Med
Chem 13(21): 2571-98.
Crump, A. (2006). "New medicines from nature's armamentarium." Trends Parasitol 22
(2): 51-4. Epub 2006 Jan 10.
Cos, P., A. J. Vlietinck, et al. (2006). "Anti-infective potential of natural products: How to
develop a stronger in vitro 'proof-of-concept'." Journal Of Ethnopharmacology 106(3):
290-302.
Rocha, L. G., J. R. G. S. Almeida, et al. (2005). "A review of natural products with
antileishmanial activity." Phytomedicine 12(6): 514-535.
Koehn, F. E. and G. T. Carter (2005). The evolving role of natural products in drug
discovery. Nature Reviews Drug Discovery 4(3): 206-220.
Balunas, M. J. and A. D. Kinghorn (2005). Drug discovery from medicinal plants. Life Sci
78(5): 431-41. Epub 2005 Sep 29.
Yamada, Y. (2002). "[Studies on discovery and synthesis of bioactive marine organic
molecules]." Yakugaku Zasshi 122(10): 727-43.
Schwikkard, S. and F. R. v. Heerden (2002). "Antimalarial activity of plant metabolites."
Nat Prod Rep 19(6): 675-692.
Fournet, A. and V. Muñoz (2002). "Natural products as trypanocidal, antileishmanial and
antimalarial drugs." Curr Top Med Chem 2(11): 1215-1237.
Chan-Bacab, M. J. and L. M. Pena-Rodriguez (2001). "Plant natural products with
leishmanicidal activity." Natural Product Reports 18(6): 674-688.
Camacho, M. d. R., J. D. Phillipson, et al. (2004). "In vitro antiprotozoal and cytotoxic
activities of some alkaloids, quinones, flavonoids, and coumarins." Planta Med 70(1): 70-
72.
Kayser, O., A. F. Kiderlen, et al. (2003). "Natural products as antiparasitic drugs."
Parasitol Res 90: S55-S62.
External Links
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| 40.3% of new chemical entities (NCEs) approved by the FDA from 1981-2002 were natural products or natural-product derivatives. Newman DJ. J Nat Prod. 2003. 1022 |