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PAN4ND
Neglected Diseases
Neglected Diseases
Neglected Diseases
The "neglected tropical diseases" are a group of 13 tropical infections that afflict poor people of
developing countries around the world. Together, they cause an estimated 500,000 to 1 million deaths
annually and cause a global disease burden equivalent to that of HIV/AIDS.
HIV/AIDS, tuberculosis, and malaria are also considered neglected diseases, even if they receive
much more media attention and research funding, and are known as the "Big 3" of neglected
diseases. Sleeping sickness, leishmaniasis and Chagas disease are considered part of the "most
neglected diseases" (WHO/IFPMA working group).
Parasitic targets
Databases ND
To be completed
Journals
PLoS Medicine
Tropical Medicine and International Health
Nature Review Drug Discovery
PLoS Neglected Tropical Diseases
Acta Tropica
American Journal of Tropical Medicine and Hygiene
Annals of Tropical Medicine and Parasitology
Annals of Tropical Pediatrics
Disease Outbreak News, WHO
Tropical Diseases Bulletin
Tropical Medicine Central Resource
Tropical Science
Journal of Antimicrobial Chemotherapy
Trends in Parasitology
The Lancet
Acta Tropica
Transactions of the Royal Society of Tropical Medicine and Hygiene
Parasitology
Advances in Parasitology
ND research-related organization
Donors
Papers
PPPs/PDPs (Public-Private Partnerships / Product Development Partnerships)
Treatments
ND Advocacy, Facts
Images
The "neglected tropical diseases" are a group of 13 tropical infections that afflict poor people of
developing countries around the world. Together, they cause an estimated 500,000 to 1 million deaths
annually and cause a global disease burden equivalent to that of HIV/AIDS.
HIV/AIDS, tuberculosis, and malaria are also considered neglected diseases, even if they receive
much more media attention and research funding, and are known as the "Big 3" of neglected
diseases. Sleeping sickness, leishmaniasis and Chagas disease are considered part of the "most
neglected diseases" (WHO/IFPMA working group).
Parasitic targets
- Human African Trypanosomiasis (sleeping sickness)
- Human American Trypanosomiasis (Chagas disease)
Databases ND
To be completed
Journals
PLoS Medicine
Tropical Medicine and International Health
Nature Review Drug Discovery
PLoS Neglected Tropical Diseases
Acta Tropica
American Journal of Tropical Medicine and Hygiene
Annals of Tropical Medicine and Parasitology
Annals of Tropical Pediatrics
Disease Outbreak News, WHO
Tropical Diseases Bulletin
Tropical Medicine Central Resource
Tropical Science
Journal of Antimicrobial Chemotherapy
Trends in Parasitology
The Lancet
Acta Tropica
Transactions of the Royal Society of Tropical Medicine and Hygiene
Parasitology
Advances in Parasitology
ND research-related organization
- MIM - Multilateral Initiative on Malaria
- TDR - the UNICEF-UNDP-World Bank-WHO Special Programme for Research and Training in
Tropical Diseases - Product development partnerships (PDPs)
- DNDi - Drugs for Neglected Diseases initiative
- IOWH - Institute for OneWorld Health
- MMV - Medicines for Malaria Venture
- TB Alliance -Global Alliance for Tuberculosis Drug Development
- Consortium to Develop New Drugs for Protozoan Diseases (CDND) @ the University of North
Carolina - Drug Discovery at Dundee
- London School of Hygiene and Tropical Medicine
- Sandler Center @ UCSF
- Swiss Tropical Institute
- Tropical Diseases Initiative
Donors
- Bill & Melinda Gates Foundation (BMGF)
- Rockefeller Foundation
- UK Department for International Development (DFID)
- Wellcome Trust
Papers
PPPs/PDPs (Public-Private Partnerships / Product Development Partnerships)
- Moran M. A breakthrough in R&D for neglected diseases: new ways to get the drugs we
need - group of 5. PLoS Medicine 2005
- Nwaka S, Ridley R. Virtual drug discovery and development for neglected diseases through
public-private partnerships. Nature Reviews Drug Discovery 2003
- Frantz S. PPPs succeeding in tackling neglected diseases. Nature Reviews Drug Discovery
2005
Treatments
- Croft, S. L., M. P. Barrett, et al. (2005). Chemotherapy of trypanosomiases and leishmaniasis.
Trends in Parasitology 21(11): 508-512.
- Croft, S. L. and G. H. Coombs (2003). Leishmaniasis- current chemotherapy and recent
advances in the search for novel drugs. Trends in Parasitology 19(11): 502-508.
- Fairlamb, A. H. (2003). Chemotherapy of human African trypanosomiasis: current and future
prospects. Trends in Parasitology 19(11): 488-494.
- Jannin, J. and P. Cattand (2004). Treatment and control of human African trypanosomiasis.
Curr Opin Infect Dis 17(6): 565-571.
- Khaw, M. and C. B. Panosian (2003). Human antiprotozoal therapy: past, present, and future.
Clinical Microbiology Reviews.
- Murray, H. W., J. D. Berman, et al. (2005). Advances in leishmaniasis. The Lancet 366(9496):
1561-1577.
ND Advocacy, Facts
- Pécoul B. New Drugs for Neglected Diseases: From Pipeline to Patients. PLoS Medicine Vol.
1, No. 1, 2004.
- Morel CM . Neglected diseases: under-funded research and inadequate health
interventions. EMBO reports, 2003
- Trouiller P, Olliaro P, Torreele E, Orbinski J, Laing R, Ford N. Drug development for neglected
diseases: a deficient market and a public-health policy failure. The Lancet, Volume 359,
Issue 9324, Pages 2188-2194
- Trouiller P, Torreele E, Olliaro P, White N,et al. Drugs for neglected diseases: a failure of the
market and a public health failure? Tropical Medicine and International Health, 2001
Images
- TDR database
- Contains over 13,000 images
- Wellcome Trust Medical Photographic Library
- Hardin Library for Health Sciences, University of Iowa
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| What is "Neglected"? “to give not enough care or attention to something that is merits your attention” -Merriam Webster Dictonary |